UPDATE: A 19-YEAR-OLD Proserpine man has died following a Whitsundays bus crash on Tuesday afternoon.
Proserpine Ambulance Station officer in charge Gavin Cousens said 11 people were injured in the crash.
"Four patients went to Mackay (Hospital), two patients were airlifted to Townsville Hospital, (and) four patients remain at Proserpine Hospital," he said.
A Queensland Police Service spokesperson said a 17-year-old man was taken to Proserpine Hospital in a critical condition, while a 25-year-old woman and a 29-year-old man were also transported, each with serious arm injuries.
A six-month old baby was also taken to Proserpine Hospital for treatment.
Mr Cousens said there were no clear signs as to how the accident occurred.
"It was a very bright, sunny day, happening on what appeared to be a straight stretch of road," he said.
"The reasons why the accident occurred at this stage are not clear."
UPDATE: THE Forensic Crash Unit is investigating following a serious single vehicle traffic crash on Shute Harbour Road in Cannon Valley this afternoon.
Initial investigations suggest at around 1pm a bus was travelling in a westerly direction from Airlie Beach to Proserpine on Shute Harbour Road when it left the roadway and crashed into a ditch.
Thirteen people, including the driver of the bus, have been injured.
A total of thirteen people have been transported to hospital, eleven to Proserpine Hospital and two to Mackay Base Hospital.
Shute Harbour Road remains closed between Gregory Cannon Valley Road and Hamilton Plains as emergency services respond to the incident.
Anyone with information which could assist with this matter should contact Crime Stoppers anonymously via 1800 333 000 or crimestoppers.com.au 24hrs a day.
Passengers injured after bus rolls on Shute Harbour Road
PASSENGERS sheltered under quickly erected tarpaulins by the side of Shute Harbour Road after the bus they were travelling on crashed this afternoon.
The passengers were travelling from Cannonvale to Proserpine when the bus left the road and rolled over at about 1pm.
The bus came to rest on its side and the front windscreen was smashed in.
Queensland Ambulance Service paramedics treated up to a dozen passengers at the scene.
Patients were transported to Proserpine Hospital including one man with head injuries and a 29-year-old woman with a "significant arm injury," a Queensland Health spokesperson said.
Senior Sergeant Nathan Blain of the Whitsunday Police said there was no passenger manifest and the exact number of passengers was not known.
"There are some very significant injuries but no one is deceased, however they are receiving medical treatment for their injuries," he said.
The cause of the accident is unknown as yet and Snr Sgt Blain said investigations were ongoing.
Motorists are advised the road will be closed for "a number of hours" and to use an alternative route between Proserpine and Airlie Beach via Gregory Cannon Valley Road.